Nanobodies is Estimated to Witness High Growth Owing to Wide Applications in Medical Industry
Nanobodies are antigen-binding fragments derived from camelid single-domain
antibodies called heavy-chain antibodies that are smaller than conventional
antibodies and synthesized through recombinant techniques. They can bind
tightly, specifically and accurately to their target molecules like
conventional monoclonal antibodies. Nanobodies find wide applications in life
sciences research, diagnostic tools, and as therapeutic agents for treatment of
various conditions like cancer, infectious diseases, inflammatory disorders,
neurological disorders, and cardiovascular diseases due to their desirable
properties including high stability, solubility, and specificity.
The global nanobodies market is estimated to be valued at US$ 1256.49 Bn in
2023 and is expected to exhibit a CAGR of 11% over the forecast period 2023 to
2030, as highlighted in a new report published by Coherent Market Insights.
Market Dynamics:
The nanobodies market is expected to witness high growth owing to wide
applications in the medical industry. Nanobodies can be developed as new
generation therapeutics and diagnostics due to their smaller size, high
solubility, stability over a wide pH range and temperature, and capability to
penetrate tissues easily compared to conventional antibodies. Their ability to
target concealed epitopes has made them very promising for diagnostic and
therapeutic uses. Moreover, recent advancements in DNA recombinant techniques
have made it possible to produce nanobodies at large scales. Nanobodies are
gaining increasing adoption as they offer promising treatment options for
conditions like cancer and infectious diseases which is expected to drive
market growth over the forecast period.
SWOT Analysis
Strength: Nanobodies have several advantages over traditional antibodies, making
them strong candidates for drug development. They are much smaller in size than
conventional antibodies, which allows better tissue penetration. Their small
size also makes nanobodies more stable and resistant to heat and pH changes.
Nanobodies can be produced economically in large quantities using various
expression systems like yeast, bacteria, and plants.
Weakness: While nanobodies show promise, their small size could also be a
potential weakness. As they are about 1/10th the size of a normal antibody,
they may not have the same effector functions to trigger immune responses.
Developing nanobodies against some targets may prove challenging due to
conformational constraints.
Opportunity: The nanobody technology enables targeting of disease sites that antibodies
cannot access. Nanobodies have opportunity in developing therapeutics for
cancer, infectious diseases, and neurodegenerative conditions. They can be
developed as diagnostic agents and used in imaging applications due to their
ability to specifically bind targets. As research progresses, more applications
of this technology are expected to emerge.
Threats: Achieving the required pharmacokinetic parameters may be difficult
with nanobodies compared to conventional antibodies. Biosimilars pose a threat
to the sales of patented nanobody drugs once they come off patent. Stringent
regulations for clinical research also increase the costs and time taken to
translate nanobody candidates into approved drugs.
Key Takeaways
The Global
Nanobodies Market Demand is expected to witness high growth over the
forecast period. Europe currently dominates the market due to presence of major
players and increasing R&D investments. Asia Pacific region is expected
grow at the fastest pace due to rising investments by pharmaceutical companies
and growing efforts to develop low-cost healthcare solutions.
Regional analysis: Europe accounts for the largest share of the global nanobodies
market led by countries like Germany, UK and Belgium. Major players in the
region are conducting clinical trials and collaborating with research
institutes for developing nanobody-based therapeutics. The market in Asia
Pacific is projected to grow at a high CAGR. This is attributed to increasing
efforts by market players towards research and production outsourcing to
low-cost regions like India and China.
Key players operating in the nanobodies market are Siemens AG, Cisco Systems
Inc., IBM Corporation, Schneider Electric SE, General Electric Company,
Honeywell International Inc., Huawei Technologies Co. Ltd., ABB Ltd., Hitachi
Ltd., Microsoft Corporation, Oracle Corporation, Johnson Controls International
plc, Black & Veatch Holding Company, Bentley Systems, Incorporated, SAP SE.
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